A multiple states metagenomic cross sectional study revealed that the vast majority of American infants showed a significant deficiency in an important bacterial strain essential for human milk utilization and immune system development. The study was conducted on 127 healthy infants aged 0-6 months across five geographically diverse states (California, Georgia, Oregon, Pennsylvania and South Carolina). The aims of the study were: (1) characterize the gut bacterial composition of healthy infants during the 0-6 months; (2) determine the metabolic potential of different gut bacterial enterotypes to utilize Human Milk Oligosaccharide (HMO); and (3) to characterize the signature of Antibiotic Resistant Genes (ARGs) in infants across the five surveyed US states.
Findings from this study found that:
Keywords: Microbiome, Non-pathogenic bacteria, Pathogenic bacteria, Bifidobacterium, Antibiotic Resistance Genes, Human Milk Oligosaccharides
Casaburi, G., Duar, R.M., Brown, H. et al. Metagenomic insights of the infant microbiome community structure and function across multiple sites in the United States. Sci Rep 11, 1472 (2021). https://doi.org/10.1038/s41598-020-80583-9