The early life determinants for Gut Dysbiosis Written by Dr Fathalla Ali, PhD (Paedatrics) 22/11/2021 The gastrointestinal tract is the home for the most diverse and populated bacterial community known as microbiota. Ideally, the gut microbiota lives in a mutually symbiotic relationship with the human body. Whilst the gut provides the well-adapted shelter, the microbiota […]
The first 1-3 years of life is an important period for the development of our gut microbiota. During this critical time, gut microbiota development progresses from it being a relatively simple microbial community that is less rich and diverse, to a one that is high in richness and diversity.
The human gastrointestinal tract is the home for trillions of bacteria that are continuously shaped by different factors and amongst these factors is the particular dietary habit followed.
Feeding human milk to newborn infants has important nutritional, physiological, immunological and psychological benefits that may impact on their long-term growth and development.
The Persistent Effects of Birth Mode on Gut Microbiota Composition, Immune System Development and Antimicrobial Resistance
It is believed that mode of birth (Vaginal or Caesarean) has a significant effect on early gut microbiota acquisition and development. Globally, the rate of caesarean birth is consistently increasing as a result of multiple factors. Among these factors are the increase in the overall income and the easy access to health facilities. In 2015, around 29.7 million births happened by caesarean, accounting for about 18% of the births in 169 countries.
It’s believed that the status of our health in later life is associated with the first bacteria that colonize our gut.
Nutrition during pregnancy is one of the most important factors that play a significant role in the early developmental process through the regulation of epigenetic mechanisms during pregnancy and neonatal periods.
Among the most abundant members of the gut microbiota that colonize the gut of infants during early days of life are Bifidobacteria, which are believed to play a major role in the development of the immune system
A multiple states metagenomic cross sectional study revealed that the vast majority of American infants showed a significant deficiency in an important bacterial strain essential for human milk utilization and immune system development.
From approximately three years of age, a child’s microbiota becomes relatively stable and continues to be so throughout their lifetime.